Do you mean the spot between your thumb and forefinger (the fleshy web area)?
If so, people are usually surprised by one of these effects, depending on context:
Common “surprising effects”
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Pressure sensitivity: That spot can feel unusually tender when pressed.
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Pain modulation: Pressing it firmly can temporarily distract from other pain (a basic nervous-system effect).
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Grip/strength illusion: Some people notice a brief change in how strong or steady their hand feels.
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Relaxation response: Slow, steady pressure can feel calming for some people.
This area is often mentioned in acupressure and is sometimes called the LI-4 (Hegu) point, though any effects are short-term and vary from person to person.
To make sure I’m answering what you meant:
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Are you asking about a physical trick,
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a health/acupressure effect, or
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a viral “try this with your fingers” illusion?
Tell me which one you saw or heard about, and I’ll explain that specific effect clearly 👍